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Professor LEE HIAN KEE
B.Sc., 1978, University of Canterbury; Ph.D., 1982, University
of Canterbury; Special Volunteer, 1991/92, National Institutes
of Health, Bethesda, USA
Contact Information
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Department of Chemistry, NUS
3 Science Drive 3
Singapore 117543
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Office: S5-02-12
Tel: (65)-6516-2995
Fax: (65)-6779-1691
Email: chmleehk@nus.edu.sg |
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Research Interests
Analytical Chemistry
Our research interests are focused on capillary electrophoresis,
liquid chromatography (LC, including nano-LC), and gas chromatography-mass
spectrometry. We have a particular interest in developing extraction
procedures like cartridge- and disk-based solid-phase extraction,
and solventless and solvent-minimised extraction  procedures such as solid- and
liquid-phase microextraction (see figure below). Other interests
in extraction are on microwave-assisted extraction, and super- and
subcritical fluid extraction. All these techniques are mainly applied
to environmental analyses although we employ them for the analysis
of molecules of biological importance as well. Some analytes of
current interest include environmental carcinogens such as heterocyclic
aromatic amines, polycyclic aromatic hydrocarbons, pesticides, phenols,
organometals, inorganic anions, endocrine disruptors and biological
compounds like steroids, chiral drugs, etc.
We are additionally interested in the LC retention behaviour of
transition metal complexes important in catalysis. We are developing
new inorganic materials for use in inorganic synthetic and industrial
catalytic reactions, including the chemical detoxification of environmental
pollutants (polychlorinated biphenyls, etc).
Representative Publications
 X. Jiang, & H.K. Lee. Dynamic Liquid-Liquid-Liquid Microextraction
with Automated Movement of the Acceptor Phase. Anal. Chem., 77,
1689-1695 (2005)
J. Zhang, T. Su, & H.K. Lee. Headspace Water-Based Liquid-Phase
Microextraction. Anal. Chem., 77, 1988-1992 (2005)
C. Basheer, S. Sindhu, H.K. Lee & S. Valiyaveettil. Development
and Application of a Simple Capillary-Microreactor for Oxidation
of Glucose with a Porous Gold Catalyst. Chem. Comm., 409-410 (2005)
C.H. Tu, L. Zhu, C.H. Ang, & H.K. Lee. Effect of NaOH on Large Volume
Sample Stacking of Haloacetic Acids in Capillary Zone Electrophoresis
with a Low pH Buffer. Electrophoresis, 24, 2188-2192 (2003)
G. Shen & H.K. Lee. Headspace Liquid-Phase Microextraction of Chlorobenzenes
in Soil with Gas Chromatography-Electron Capture Detection. Anal.
Chem., 75, 98-103 (2003)
L. Zhu, C.H. Tu & H.K. Lee. On-Line Concentration of Acidic Compounds
by Anion-Selective Exhaustive Injection-Sweeping-Micellar Electrokinetic
Chromatography. Anal. Chem., 74, 5820-5825 (2002)
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