| |
|
|
|
|
 |
Associate Professor LAM YULIN
B.Sc.(Hons), 1987, National University of Singapore; Ph.D., 1992, National University of Singapore; Research Fellow, 1992-1994 The Scripps Research Institute; Research Fellow, 1994-1996 Institute of Molecular and Cell Biology
Contact Information
|
|
Department of Chemistry, NUS
3 Science Drive 3
Singapore 117543
|
Office: S5-03-04
Tel: (65)-6516-2688
Fax: (65)-6779-1691
Email: chmlamyl@nus.edu.sg |
|
Research Interests
Combinatorial and Bioorganic Chemistry
Combinatorial chemistry is a powerful technology allowing simultaneous
preparation of diverse, novel and biologically active molecules
for drug discovery and development. By utilising combinatorial approaches,
we are interested in synthesizing and screening libraries of compounds
which exhibit diverse biological activities. We are particularly
interested in exploiting the technology to (i) search for compounds
with antibacterial, antiviral and antimicrobial properties; and
(ii) develop inhibitors to human multi-resistance proteins.
Additionally we are also interested in (i) investigating the use
of new linkers which are both cost-effective and chemically useful
for solid-phase combinatorial synthesis. We are presently examining
the use of sodium benzenesulfinate resin as a solid-support for
combinatorial synthesis; and (ii) developing soluble polymers for
liquid-phase combinatorial synthesis.
Representative Publications
Combinatorial and Bioorganic Chemistry
 J Che, M S Raghavendra and Y L Lam. "Traceless Solid-Phase Synthesis of Hetero-annulated 1,3-Oxazin-6-ones" J Comb Chem, 2009, 11, 378-384.
L K Wong, Y L Lam and A J Melendez. "Synthesis And Evaluation Of Sphingosine Analogues As Inhibitors Of Sphingosine Kinases" J Med Chem, 2009, 52, 3618-3626.
Y Gao and Y L Lam. "Polymer-Supported N-Phenylsulfonyloxaziridine (Davis Reagent): A Versatile Oxidant" Adv Synth Cat, 2008, 350, 2937-2946
Y Gao and Y L Lam* "[3+2] Cycloaddition Reactions in the Synthesis of Triazolo[4,5-b]pyridin-5-ones and Pyrrolo[3,4-b]pyridin-2-ones" J Comb Chem, 2008, 10, 327-332.
R He, P H Toy and Y L Lam. "Polymer-Supported Hantzsch 1,4-Dihydropyridine Ester: An Efficient Biomimetic Hydrogen Source" Adv Synth Catal, 2008, 350, 54-60.
C H Soh, W K Chui and Y L Lam. "An Expedient Synthesis of Di- and Mono- Substituted 2-aminoimidazoles" J Comb Chem, 2008, 10, 118-122.
R He and Y L Lam. "An Efficient Solid-phase Synthesis of 3-Substituted and 3,3-Disubstituted 1,2-Dialkylpyrazolidine-3,5-diones" Org Biomol Chem, 2008, 6, 2182 - 2186
H Fu and Y L Lam. "Regiospecific Solid-Phase Strategy to N7-Substituted Purines and Its Application to 8-Azapurines and [i]-Condensed Purines" J Comb Chem, 2007, 9, 804-810.
T M C Tan, F Yang, H Fu, M S Raghavendra, Y L Lam. "Design, Synthesis and Biological Evaluation of Novel Purine Analogs as Inhibitors of Multidrug Resistance Protein 4 (MRP4/ABCC4)" J Comb Chem, 2007, 9, 210-218.
R He, S M Ching and Y L Lam. "Traceless Solid-Phase Synthesis of Substituted Xanthines" J Comb Chem, 2006, 8, 923-928.
C H Soh, W K Chui, Y L Lam. "Efficient Synthesis of 2,4-Disubsituted-5-Aminoimidazoles Using Microwave Irradiation" J Comb Chem, 2006, 8, 464-468
Y Gao and Y L Lam. "[3+2] Cycloaddition Reactions in the Solid-phase Synthesis of 1,2,3-Triazoles" Org Lett, 2006, 8, 3283-3285
T M C Tan, Y Chen, K H Kong, J Bai, Y Li, S G Lim, T H Ang and Y L Lam. "Synthesis and the Biological Evaluation of 2-Benzenesulfonylmethyl-5 Substituted-Sulfanyl-[1,3,4]-Oxadiazoles as Potential Anti-Hepatitis B Virus Agents" Antiviral Res, 2006, 71, 7-14.
R. He and Y L Lam. "A Highly Efficient Solid-phase Synthesis of 1,3-Substituted Xanthines" J Comb Chem, 2005, 7, 916-920.
W Li and Y L Lam. "A Facile Solid-phase Synthesis of 1,2,4,5-Tetrasubstituted Imidazoles Using Sodium Benzenesulfinate as a Traceless Linker" J Comb Chem, 2005, 7, 644-647.
W Li and Y L Lam. "Solid-Phase Synthesis of 3,4-Dihydro-1H-pyrimidine-2-ones Using Sodium Benzenesulfinate as a Traceless Linker" J Comb Chem, 2005, 7, 721-725.
H Fu and Y L Lam. "Traceless Solid-Phase Synthesis of N1, N7-Disubstituted Purines" J Comb Chem, 2005, 7, 734-738.
K H Kong, Y Chen, X Ma, W K Chui and Y L Lam. "Traceless Solid-phase Synthesis of Nitrogen-containing Heterocycles and Their Biological Evaluations as Inhibitors of Neuronal Sodium Channels" J Comb Chem, 2004, 6, 928-933.
W Li, Y Chen and Y L Lam. "A Facile Solid-Phase Synthesis of 3,4,6-Trisubstituted-2-Pyridones Using Sodium Benzenesulfinate as a Traceless Linker" Tetrahedron Lett, 2004, 45, 6545-6547.
M S Raghavendra and Y L Lam. "Regiospecific Solid-Phase Synthesis of Substituted 1,2,3-Triazoles" Tetrahedron Lett, 2004, 45, 6129-6132.
Y Chen, Y L Lam and Y H Lai. "Solid-phase Synthesis of Pyrazolines and Isoxazolines with Sodium Benzenesulfinate as a Traceless Linker" Org Letts, 2003, 5, 1067-1069.
Y Chen, Y L Lam and Y H Lai. "Solid-phase Synthesis of Imidazo[1,2-a]pyridine Using Sodium Benzenesulfinate as a Traceless Linker" Org Letts, 2002, 4, 3935-3937.
Yu Chen, Y L Lam and Soo-Ying Lee. "Solid Phase Synthesis of Pyridazine Derivatives Using Polymer-Bound Sodium Phenyl Sulfinate" Chem. Lett, 2001, 274-275.
C L Lee, K P, Chan, Y L Lam and Soo-Y Lee. "Solid-phase Combinatorial Synthesis of 1,4-Benzoxazin-3(4H)-one and 1,4-Benzothiazin-3(4H)-one Derivatives" Tetrahedron Letts, 2001, 42, 1167-1169.
C L Lee, Y L Lam and Soo-Y Lee. "Solid-Phase Combinatorial Synthesis of Benzothiazole and 2,3-Dihydro-[1,5]-Benzothiazepine Derivatives" Tetrahedron Letts, 2001, 42, 109-111. |
|
