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SP1201 - Seminar Topics in AY2009/10
Please take note of the corresponding lecture group in order to bid for the correct seminar in CORS.
The Global Impact of Biological Computing This seminar is given by Prof Christopher W. V. Hogue who is an Associate Professor at the Department of Biological Sciences at the National University of Singapore. Chris received his Honours B.Sc. in Biochemistry from the University of Wiindsor and his Ph.D. in Biochemistry from the University of Ottawa. A self-taught software developer and architect, he did his Postdoctoral training in Bioinformatics and Computational Biology at NCBI as a Genbank Fellow. Highly cited with over 50 peer reviewed papers, he has an ongoing academic interest in wet-lab research involving the validation of protein-protein and protein-small molecule interactions. Formerly at the University of Toronto, Dr. Hogue was the Principal Investigator on Genome Canada's largest Bioinformatics research grant to date - the BIND Project. BIND is recognized as the first and most complete molecular interaction database of its kind. The intellectual property behind his research - including BIND and over a million lines of source code - was acquired by Thomson Scientific in 2007. [Back to Table]
Biological Machines Professor Matsudaira is a molecular cell biophysicist who is the Head of Biological Sciences, Director of the NUS Centre for BioImaging Sciences, and co-Director of the Research Centre of Excellence in Mechanobiology. From 1985-2008, he was at the Whitehead Institute and Massachusetts Institute of Technology where he was Professor of Biology and Bioengineering. His lab studies the biophysics of cell migration. He is devoted to teaching undergraduates and is an author of the textbook, Molecular Cell Biology. While at MIT he introduced and taught Fundamentals of Biology, Experimental Biology, and the largest freshman seminar, Introduction to Biological Engineering. [Back to Table]
From Toxins to Therapeutics Professor Manjunatha Kini obtained his PhD in Biochemistry from the University of Mysore, India. After postdoctoral training in Kyushu University (Japan) and Virginia Commonwealth University (US), he joined NUS in 1994. He is a protein chemist by training and has been interested in structure-function relationships and mechanism of action of snake venom toxins. He is one of the most cited authors in the field of toxins. He has developed a number of therapeutic agents based on the structure of toxins. He teaches protein chemistry, protein design and engineering. [Back to Table]
The Biodiversity Crisis in Tropical Asia Professor Richard Corlett obtained his BA in Natural Sciences from the University of Cambridge before doing his PhD at the Australian National University, with fieldwork in Papua New Guinea. He has since lived and worked in tropical Asia, teaching ecology at the University of Chiang Mai, at NUS, at the University of Hong Kong, and now again at NUS. Much of his research has focused on plant-animal interactions, but he has also worked on tropical biogeography, and the impacts of deforestation, invasive species and climate change. His new book on the Ecology of Tropical East Asia will be published this year. . [Back to Table]
Electrochemical Phenomena: From Clean Energy to Pollutant Sensors Dr Toh obtained his Bachelor of Science (Hons) and carried out the Masters of Science research studies at the National University of Singapore. He subsequently further his graduate studies at the University of Southampton, U.K., working with Phil Bartlett on electrochemical biosensors. Thereafter, he continued his postdoctoral work at the California Institute of Technology with Nathan Lewis on electrochemical nanostructured materials. His general interest is electrochemistry and his current research interests are in the developments of new sensing and separation techniques using nanostructured membrane electrodes, electrode-membrane-electrode system and electroanalytical methods. [Back to Table]
From Magic to a Modern Science - The Changing History of Chemistry Dr. Zhao Jin obtained the Bachelor degree in the department of chemistry in Liaoning University in 1992 and the Master degree in Changchun physical institute of Chinese Academy of Science in 1995. After 5-year teaching and research work, she has been granted by DAAD (German Academic Exchange Service) for the PhD work in the department of chemistry of Technische Universitaet Muenchen in Germany from 2001 to 2005. After one-year postdoctoral work, she joined NUS. Currently she is a lecturer in the department of chemistry. Her research interest is organometallic chemistry and catalysis and she has published about 30 international papers. [Back to Table]
Mathematics and Computer Science A/P Frank Stephan has studied computer science in Karlsruhe and received a Diploma in Computer Science in 1989. He continued his studies in mathematics and received a Doctorate of Natural Sciences in 1990. In 1999 he received from the Faculty of Mathematics of the University of Heidelberg the habilitation degree. Frank Stephan has worked in the fields of recursion theory and inductive inference since 1990 and has published about 70 research articles in journals so far. He has been working at the universities of Karlsruhe, Heidelberg, New South Wales (Sydney) before he came to Singapore to join the National University of Singapore. [Back to Table]
Analogy and Intuition in Mathematics A/P Leong Yu Kiang is an Associate Professorial Fellow at the Department of Mathematics. He obtained his B Sc (Hons) in 1969 from the University of Singapore and his Ph D (in group theory) in 1972 from the Australian National University. He has been teaching at the University of Singapore and National University of Singapore since 1972. He was Chairman of the Department’s Curriculum Committee from 1995 to 2003 and an Academic Advisor to the Open University Degree Programmes (conducted by the Singapore Institute of Management) from 1993 to 2005. He has held offices of the Singapore Mathematical Society from 1974 to 1998 as Committee Member, Editor, Honorary Secretary and Vice-President. He was editor of the Institute for Mathematical Sciences newsletter “Imprints” from 2003 to 2005. [Back to Table]
Is Computer Science Science? Prof Y.C. Tay received his B.Sc. degree from the University of Singapore and Ph.D. degree from Harvard University. He is a professor in the Departments of Mathematics and Computer Science. He has spent sabbaticals at Princeton University, Massachusetts Institute of Technology, Cambridge University, Microsoft Corporation and Intel Research. He has multiple teaching awards. His main research interest is performance modeling of computer systems. [Back to Table]
The Physics of Time
Everyone knows what time is, yet when pressed to explain what it really is, few would be able to give a satisfactory scientific answer. The purpose of this Freshman Seminar is to introduce freshmen to the modern ideas and physical theories regarding time, and to enable them to distinguish scientific fact from science fiction. Amongst the questions that would be dicussed are: What is time? How do we measure time? What is the theory of relativity? What are the arrows of time? Is time travel possible? What are the possible paradoxes involving time travel?
A/P Edward Teo received his Ph.D. from the University of Cambridge in 1994. He joined NUS in 1997, and is presently an Associate Professor in the Department of Physics, carrying out research into black holes. [Back to Table]
Matter and Interaction Dr Goldman is currently a lecturer at the Physics Department. [Back to Table]
Statistics as an Integral Part of Science and Society
The goal of this seminar will be to introduce students to the role that statistics plays in scientific research as well as in understanding society. The focus will be on introducing students to real-world problems - from various fields of science as well as society in general - for which statistics reasoning is an important component and to show how statistical thinking can help in finding solutions. Instruction will be provided on several commonly used statistical methods but the focus will be on linking the statistics with the underlying scientitic or societal problem. Emphasis will be placed on self-evaluation of statistical reasoning, interpretation of results, and the development of statistical judgement.
Dr Lim joined NUS in 1998 after completing his PhD in Statistics at Stanford University. He is currently Deputy Head (Academic) of the Department of Statistics and Applied Probability. His research areas are in mathematical finance and financial statistics; he is particularly interested in optimal stopping and stochastic control problems in finance. [Back to Table]
DNA Strands - 2 Strands, 3 Men, 1 Dark Lady
Prof Ding Jeak Ling obtained her PhD in Biochemistry/Molecular Biology from the Royal Postgraduate Medical School, University of London. Her research is on host-pathogen interaction and innate immunity (first line of defense), particularly on how pathogen-recognition receptors interact with each other during the acute phase infection, to alarm and send signals into the host cells of the imminent infection-inflammation (ref: http://www.dbs.nus.edu.sg/staff/djl.htm) . She teaches biochemistry, molecular biology and biotechnology. [Back to Table]
Understanding the Fundamentals of Biotechnology
The emergence and success of the biotechnology industry depends on major scientific breakthroughs in biology. The module will focus on four of the most important discoveries in biology, and to examine the sciences behind these discoveries, and their contribution and impact to the industry. Specifically, we will study (1) the discovery of DNA double helix as the foundation of modern biology (2) the discovery of restriction enzymes for the advent of recombinant DNA technology (3), the complete sequencing of human genome as the basis for molecular medicine and (4) the development of cloning and embryonic stem cells for modern regenerative medicine.
Prof. Hew received his PhD at the University of British Columbia and postdoctoral trainings at Yale and University of Toronto. He was earlier a professor at University of Toronto and the Research Institute, Hospital for Sick Children, Toronto. From 1999- 2008, he was the Head, Department of Biological Sciences, at NUS. Prof. Hew is a biochemist interested in the structure and function of proteins, gene regulation and control mechanisms, marine biology and biotechnology applications. His research laboratory has studied the biology of fish antifreeze proteins, their adaptation mechanisms as well as applications in agriculture and the cryo-related industries; the development of transgenic fish; and the structural and functional genomics of viral pathogens important in the aquaculture industry. [Back to Table]
Why are studies on plant biology important?
Why should we study plants? The combined annual global production of food grains including, rice, wheat, corn, barley and soybean, reaches astronomical quantities. Production of milled rice alone was about 417 million tons in 2006/07, which would be equivalent to over $400 billion at an average price of $1000 per ton. Besides being the primary source of food and oxygen for all animals, including human beings, plants share numerous basic biological processes with animals. Many of the molecular genetic processes underlying cell division and development in animals can be traced to parallel processes occurring in plants, which had evolved much earlier than animals. This module will explore the similarities and differences in some of the major biological processes such as signal transduction and cell division in plant and animal systems. Students will explore these basic developmental events and how such information can be used for improving productivity of agricultural crops. Discussions will also cover the use of plants (including genetically modified crops) as sources of food, fuel and other commercial products.
Professor Prakash Kumar is a plant developmental biologist who earned his PhD degree from the Department of Biological Sciences, University of Calgary, Canada. He joined NUS in 1989 and during the last 20 years he has been working on plant developmental biology research with focus on tissue culture, molecular biology and biotechnology. A recent discovery from his lab is currently being explored as a method to enhance yield of crops such as rice. He is well recognized by his peers internationally and he has been appointed as an Editor of several international scientific journals in his research expertise. [Back to Table]
Idols of the Mind
Is there a universal set of rules for discovering and testing scientific hypotheses? Since the birth of modern science, many thinkers have wrestled with this fundamental question of scientific practice. Can we approach a natural phenomenon with a tabula rasa as envisioned in the philosophy of Bacon or do the idols of the mind predetermine the hypotheses that we might test? Indeed what role does chance play in scientific discovery? For that matter, what is science and what are its limits? This seminar will investigate many questions which are philosophical in nature within the context of many of the great ideas that permeate our current worldview from evolution and DNA to relativity and quantum theory. Reading this seminar, the student will gain insights not only into the way scientists think and work, but also an understanding of how many of the great ideas of science came into being. Students will develop an appreciation of the status of scientific theories and their relationship to observational data, the extent to which scientific theories rest on improvable paradigms, and the nature of scientific explanations. [Back to Table] Learning to Fish (Molecular Science) from the Open Sea (Research Literature)
We live in a molecular era when molecular science and technology is the focus of many contemporary research areas such as environment, energy, chemical biology, electronics and chemical processes. Yet, how many of us fully understand what "molecular science" entails? What does it mean? What does it include? Where are the boundaries? How are they applied? So what, if we knew little about it? In this series of seminars, we shall analyse the nature and impact of this field. We approach this not from the basic textbooks, but from the other end of the reference -"Hot-from-the-oven" open scientific literature. We shall focus on the trunk that shapes the molecular science, i.e. molecules. The class will identify representative systems from the research literature, start from the top, and trace back to its root. We call this "molecular journey". In this journey, we examine the concepts that have evolved over the years as well as the inventors of the "classic molecules", and the legacy that they left behind.
Andy Hor is Professor of Chemistry in NUS. He has published over 230 international papers in molecular assembly, heterometallic syntheses and catalysis. He won the University Educator Award in 2001, Faculty Outstanding Scientist Award in 2007, and an accolade of teaching excellence awards. He is a synthetic chemist whose team single-mindedly makes molecules, examines their structures and explores their functions. His research doctrine is simple -if it is not exciting, it is not worth doing. His teaching principle is guided by the five C's -Creativity, Commitment, Communication, Common sense, and, Chemistry! He was an Imperial College (B.Sc.(Hon) and Oxford (D.Phil.) graduate, who had carried out his postdoctoral research in Yale before he joined NUS. [Back to Table]
The Five S's of Molecules
We live in a molecular world, when many current science subjects seem to gravitate towards molecules. Examples are plentiful, such as "Molecular Biology", "Molecular Genetics", "Molecular Electronics", "Molecular Medicine", "Molecular Informatics", "Molecular Engineering", "Molecular Pharmacology", "Molecular Ecology", "Molecular Machines"... etc. In the "Science of Molecules" viz. "Chemistry", the focus is on molecular design, molecular structure, molecular synthesis, molecular activity and molecular function. The function depends on the activity, which in turn is governed by the design and structure. Chemical synthesis is generally guided by good structural design. Molecular structures therefore are the fundamentals in molecular science. In this seminar series, we shall discuss with the class the underlying principles of chemical structures, with specific focus on the interrelationship among the five S's of molecules -Science, Structure, Stability, Symmetry, and, Space. The mode of teaching and learning focuses on group learning, interaction, independent enquiry, project work, molecular models, and public presentations. Writing and presentations are essential elements in this freshmen seminar.
Andy Hor is Professor of Chemistry in NUS. He has published over 230 international papers in molecular assembly, heterometallic syntheses and catalysis. He won the University Educator Award in 2001, Faculty Outstanding Scientist Award in 2007, and an accolade of teaching excellence awards. He is a synthetic chemist whose team single-mindedly makes molecules, examines their structures and explores their functions. His research doctrine is simple -if it is not exciting, it is not worth doing. His teaching principle is guided by the five C's -Creativity, Commitment, Communication, Common sense, and, Chemistry! He was an Imperial College (B.Sc.(Hon) and Oxford (D.Phil.) graduate, who had carried out his postdoctoral research in Yale before he joined NUS. [Back to Table]
Appreciation of Basic Results in Mathematics - Prime numbers and the Fundamental Theorem of Arithmetic
Koh Khee Meng is Professor at the Department of Mathematics. He obtained his PhD from the University of Manitoba in Canada in 1971. Among several other significant appointments, Professor Koh was the chairman of the Singapore International Mathematical Olympiad Committee (1991-93), a council member of the Institute of Combinatorics and Its Applications (International) (1995-97) and the president of the Singapore Mathematical Society (1996-98). He has also won numerous Teaching Awards from the Faculty of Science, NUS. Professor Koh specializes in Combinatorics and Graph Theory and has had many papers published in international scientific journals. He is co-author of the books: Principles and Techniques in Combinatorics, College Mathematics Volumes 1 & 2, Counting, Counting (Supplementary Notes and Solutions Manual), Chromatic Polynomials and Chromaticity of Graphs, Introduction to Graph Theory-H3 Mathematics and Introduction to Graph Theory-H3 Mathematics (Solutions Manual). [Back to Table]
Mathematics in Science, Technology and Society
Prof S. L. Lee obtained a Ph.D. degree in Mathematics from the University of Alberta, Canada, in 1974 under a Canadian Commonwealth Scholarship. He was a receipient of several research grants, including a French CNRS fellowship (1980), a U.K. NSERC research grant (1986) and an NSTB (former A*STAR) grant (1995) for his research in spline functions, wavelets and approximation. His research interests also include applications to information processing and geometric modeling. He was a winner of the Singapore National Science Award in 1998. [Back to Table]
Are We Alone?
How did life originate on Earth? What are its building blocks? What physical conditions are necessary for life? Are these conditions and building blocks common elsewhere in the universe? How likely is it for complex and intelligent life to evolve even if simple life-forms develop elsewhere? Is it necessary for potential life elsewhere to be based on a similar biochemistry to that on earth? How then would one detect and recognize life elsewhere? How would we communicate with potential intelligent life elsewhere in the universe? Why have not been contacted so far, or have we? Based on readings, discussions, presentations and project work, the students will explore these questions that have fascinated not just the laymen but an increasing number of scientists working in the interdisciplinary field of Astrobiology.
The website for the seminar series is : http://staff.science.nus.edu.sg/~parwani/origins/originsindex.html [Back to Table]
Thinking Like a Scientist
Dr Roland Su obtained both BSc and PhD in Physics from University of Bristol (UK). He joined NUS in 1999, and became Director of the Education programme for Gifted Youth (NUS-EPGY) in 2001. From 2000-2004 he was concurrently the Science coordinator for the MOE SM2 scholarship programme, a bridging programme for talented youth from China. Between 2004-2005, he was the Assistant Principal of the NUS High School of Mathematics and Science, pioneering the setting up of programmes for idetifying and nuturing gifted youths. Currently, Dr Su teaches undergraduate Physics and is the Associate Dean (Study Abroad Programmes) at the Science Dean's Office. [Back to Table]
Conceptual Development of Physics
Prof Oh Choo Hiap is a Physicist whose research interests are in High Energy Physics, Yang-Mills gauge field theories, Quantum Algebra, Yang-Baxter equations and Quantum Information Science. [Back to Table]
The Beauty of Symmetry
Dr. WANG Qinghai was born in China. He received his B.Sc. and M.Sc. from the University of Science and Technology of China and his PhD in Physics from Washington University in St. Louis (USA). Before joining NUS, he worked as a postdoctoral fellow in the University of Connecticut (USA). [Back to Table]
Randomness in Scientific Thinking
Dr Alex Cook is a statistician whose research area is in modelling and inference for infectious diseases and ecology. Before joining NUS in 2008, Cook was a visiting scholar in the department of plant sciences, University of Cambridge, and a research associate in the department of actuarial mathematics and statistics at Heriot-Watt University, Scotland. He did his PhD at Biomathematics and Statistics Scotland. [Back to Table]
Statistical Game Theory
Dr Alex Cook is a statistician whose research area is in modelling and inference for infectious diseases and ecology. Before joining NUS in 2008, Cook was a visiting scholar in the department of plant sciences, University of Cambridge, and a research associate in the department of actuarial mathematics and statistics at Heriot-Watt University, Scotland. He did his PhD at Biomathematics and Statistics Scotland. [Back to Table]
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