Vitamin D deficiency in kidney disease patients in Singapore
11 Jul 2014. Vitamin D deficiency was found to be prevalent among multiethnic non-dialysis chronic kidney disease (CKD) patients in Singapore.
Despite being a sun-rich country, the majority of non-dialysis CKD patients in Singapore were found to have suboptimal vitamin D status. Vitamin D deficiency is associated with mineral and bone disorder in these patients. The study, conducted by a team led by Professor Priscilla HOW from Department of Pharmacy NUS, found that 87% of 196 patients in the group of non-dialysis CKD patients at a local academic medical center were vitamin D insufficient or deficient . Although vitamin D levels were comparable among patients at various CKD stages, the prevalence of vitamin D deficiency was highest in patients with stage-5 CKD. The prevalence of vitamin D deficiency was also highest amongst female patients and those of Malay and Indian ethnicity. Several risk factors were found to be associated with this deficiency, including absence of vitamin D supplementation, diabetes, non-cancer diagnosis, young age. “The survey results are significant as they provide a guide for local healthcare professionals to make decisions on vitamin D supplementation for patients who are at risk, before their kidney function deteriorates.” said Prof HOW. The results also help clinicians to decide to start vitamin D therapy early to prevent complications associated with its deficiency (see Figure).
The synthesis of vitamin D (Image credit: Priscilla HOW. The role of the pharmacist in the identification and management of secondary hyperthyroidism. US Pharmacist, July 2007).
- Ngai M, Lin V, HC Wong, Vathsala A, How P. "Vitamin D Status and its Association with Mineral and Bone Disorders in a Multi-Ethnic Chronic Kidney Disease Population in Southeast Asia." Clin Nephrol (in press).
- Loh ZY, Yap CW, Vathsala A, How P. "Clinical and Demographic Predictors for Vitamin D Deficiency in Multi-Ethnic Asian Patients with Chronic Kidney Disease." Clin Kidney J 5 (2012) 303.